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> Suppository
chemistry
Suppository

Alfa's partner, Gattefossé, offers a comprehensive range of suppository bases under the trade name of Suppocire®.

We can offer expert formulation advice and can draw on a library of formulations to enable fast development of your suppository. Suppocire bases are adapted to solve problems such as high powder loading and poor bioavailability.

Suppocire® Range


  • Inert solid dosage form for rectal / vaginal applications
  • Originated by hydrogenated vegetable oils
  • Regulatory status: conformity to current edition US/EP/JP
  • Disperse active ingredient
  • Melt or soften at body temperature
  • Amphiphilic properties
  • Chemically stable (against oxidation)
  • Narrow melting range
  • Batch-to-batch reproducibility

For expert advice from our technical department on solving your formulation problems, or to request further information or samples of any of our suppository bases, please contact us or submit your query via the info request form.

SUPPOCIRE® "STANDARD" TYPE


Obtained by "interesterification" between hydrogenated palm oil and hydrogenated palm kernel oil

  • Self-lubricating due to the MCT
  • Inert
  • Excellent mucosal tolerance
  • Low polymorphism potential
  • Low rancidity

 
 
  Product Hydroxyl Value (mg KOH/g)
Melting Point (C)
AM <10 35 - 37
AML <10 35 - 37
BM <10 36 - 38
CM <10 38 - 40
DM <10 38 - 40
AS2 15 - 25 35 - 37
BS2 15 - 25 36  - 38
A 20 - 30 35 - 37

SUPPOCIRE® "N" TYPE


Obtained by "direct esterification" between fatty acids and glycerol

  • High mechanical resistance
  • Inert
  • Excellent mucosal tolerance
  • Low polymorphism potential
  • Low rancidity

 
 
  Product Hydroxyl Value (mg KOH/g)
Melting Point (C)
NA 10 5 - 15 33 - 36
NA 15 5 - 15 33 - 36
NA 20 - 30 33 - 36
NB 20 - 30 36 - 38
NA|50 >30 33 - 36

SUPPOCIRE® "P" TYPE


Obtained by "direct esterification" between hydrogenated vegetable oil and PEG

  • Enhanced solubilization
  • Inert
  • Improved bioavailability of drug

 
 
  Product Hydroxyl Value (mg KOH/g)
Melting Point (C)
AP 25 - 35 33 - 35
BP 25 - 35 35 - 37
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