ALFA

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Formulation
Development

Functional Excipients

> Oral

> Topical

> Emulsifiers

> Solubilisers

> Microemulsions

> Thickening agents/emolients

> Suppository

Topical

Solubilisers

Improving topical drug delivery

Alfa’s partner, Gattefossé, provides innovative, safe and cost effective excipients for the development creams, lotions, gels and microemulsions.

These excipients help combine pharmaceutical quality, therapeutic efficacy and consumer acceptability into distinct topical formulations designed to:

Improve drug delivery
Emulsify poorly soluble drugs
Improve product stability

Improve product aesthetics and feel
Improve process parameters
Reduce manufacturing costs

Solubilisers

To improve and optimise topical drug delivery, solubilisers may be added to the formulation. Gattefossé’s solubilisers can be used alone, or in combination in emulsions to optimize delivery of the actives.

For expert advice from our technical department on solving your formulation problems, or to request further information or samples of any of our excipients, please contact us or submit your query via the info request form.

Mark tick box to add excipient to info request form

	Product	Chemical Description	HLB Value	Regulatory Status	Applications
	Capryol 90	Propylene glycol monocaprylate	6	FCC/USFA/JSFA	Oily vehicle used as solubilizer.
	Capryol PGMC	Propylene glycol caprylate	5	FCC/USFA/JSFA	Oily vehicle used as solubilizer
	Labrafil® M 1944 CS	Oleoyl macrogolglycerides	4	USP-NF EP	Oily vehicle used as co-emulsifier.
	Labrafil® M 2125 CS	Linoleoyl macrogolglycerides	4	USP-NF EP	Oily vehicle used as co-emulsifier.
	Labrafil® M 2130 CS	Lauroyl macrogolglycerides	4	EP	Oily vehicle used as co-emulsifier.
	Labrasol	Caprylocaproyl macrogolglycerides	14	USP-NF EP	Surfactant with remarkable drug solubilizing properties in gels and microemulsions.
	Lauroglycol 90	Propylene glycol monolaurate	5	USP/EP/jped FCC/USFA/E477/JSFA	Oily vehicle used as solubilizer.
	Lauroglycol FCC	Propylene glycol laurate	4	USP/EP/jped FCC/USFA/JSFA	Oily vehicle used as solubilizer.
	Plurol® Oleique CC 497	Polyglyceryl oleate	6	jped/FCC/GRAS E475/JSFA	Oily vehicle used as solubilizer.

Solvent
	Product	Chemical Description		Regulatory Status	Aplications
	Transcutol® P	Diethylene glycol monoethyl ether		USP-NF/EP	Powerful solubilizer and drug depot agent.