Divisions > Pharmaceutical > Excipients > Suppository > Suppocire Standard
Suppository Bases
Suppocire® Standard
Suppocire® Standard products contain a well-defined proportion of mono/di and triglycerides. Their physicochemical features are adapted to meet the needs of different Active Pharmaceutical Ingredient (API) properties, formulation and manufacturing operations.
Standard AI, A, B, C & D Product Lines
Suppository bases obtained by inter-esterification of hydrogenated palm oil and hydrogenated palm kernel
oil. These are multipurpose vehicles covering a range of melting points (drop point).
- Result in a softer suppository unit which is self lubricating due to the well-defined medium chain triglyceride content.
- Ideal for straightforward formulations and versatile for use with manual, semi and fully automated manufacturing equipment
P line
Bases consist of polyglycolized glycerides synthesised by esterification of selected fatty acids with polyethylene glycol (PEG) and glycerol.
- The amphiphilic base provides bioavailability enhancement through improved solubilization and absorption of API
- Suitable for difficult to formulate active ingredients
M Grade
Suppository bases derived from the AI, A, B, C & D product lines (obtained by inter-esterification of hydrogenated palm oil and hydrogenated palm kernel oil). The low hydroxyl value / low reactivity ensures:
- Minimal risk of interaction between free OH groups and acidic active ingredients.
- High crystallization rate in individual suppository units.
- Suitable for high-speed manufacturing.
- Suitable for sensitive APIs.
N line
Bases obtained by direct esterification of selected fatty acids with glycerol. The long chain triglyceride content confers rapid solidification resulting in harder suppository units with high mechanical resistance. The low hydroxyl / low reactivity products provide:
- High crystallization rate in individual suppository unit.
- Appropriate for high through-put / high speed manufacturing equipment.
- Suitable for sensitive active ingredients.
The higher hydroxyl value products provide versatility for lower volume / lower speed production equipment.
Technical Support
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