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Sustained release agents

Through our sister company Gattefossé (UK) Ltd we can offer the full range of Gattefossé lipid excipients for oral drug delivery.

Gattefossé lipid excipients provide straightforward solutions for the development of effective sustained release dosage forms. A sustained release dosage form can be created using lipid excipients to form either a water insoluble matrix or a hydrophobic film around an active drug. A range of formulation techniques are available including direct compression, solid dispersions, spray cooling and melt granulation that enable the development of a variety of sustained release dose forms including tablets, capsules, granules and pellets.

Benefits of using Gattefossé lipid excipients for sustained release formulations include:

  • Production of SR matrices with pH-independent drug release kinetics and avoidance of burst release kinetics
  • High compatibility with API and additional functional ingredients providing scope for propriety innovation
  • Simple formulation techniques that yield highly stable drug release profiles
  • Utilize standard laboratory and industrial equipment
  • Solvent-free processing for cleaner production

For more information on how to formulate a sustained release dosage form please contact us, or visit the Sustained Release Formulation Guide on this website.

Products

Sustained release agents
Product Name Chemical Description More Information Add to My Enquiry
Compritol® 888 ATO Glycerol dibehenate EP, Glyceryl behenate NF
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Additional Regulatory Information IIG/JSFA/FCC/GRAS
HLB Value 2
Melting Point °C 70
Recommended formulation techniques / Applications Compression, Spray-cooling/Prilling, Melt granulation/Melt extrusion
Geleol™ Mono and Diglycerides NF Glycerol monostearate (type I) EP, Mono and diglycerides NF
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Additional Regulatory Information IIG/JSFA/E471/FCC/GRAS
HLB Value 3
Melting Point °C 56.5
Recommended formulation techniques / Applications Spray-cooling/prilling, Melt granulation/Melt extrusion, Capsule molding
Gelucire® 39/01 Hard fat EP/NF
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Additional Regulatory Information IIG/JSFA/JPED/USFA/DSHEA
HLB Value 1
Melting Point °C 39
Recommended formulation techniques / Applications Melt granulation/Melt extrusion, Capsule molding
Gelucire® 43/01 Hard fat EP/NF
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Additional Regulatory Information IIG/JSFA/JPED/USFA/DSHEA
HLB Value 1
Melting Point °C 43
Recommended formulation techniques / Applications Melt granulation/Melt extrusion, Capsule molding
Gelucire® 50/13 Stearoyl macrogol-32 glycerides EP, Stearoyl polyoxyl-32 glycerides NF
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Additional Regulatory Information IIG/USFA
HLB Value 13
Melting Point °C 50
Recommended formulation techniques / Applications Capsule molding
Precirol® ATO 5 Glycerol distearate (type I) EP, Glyceryl distearate NF
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Additional Regulatory Information FCC/GRAS/IIG/JSFA
HLB Value 2
Melting Point °C 56
Recommended formulation techniques / Applications Spray-cooling/prilling, Melt granulation/Melt extrusion, Capsule molding